Transmasculine HRT

Transmasculine HRT uses testosterone to bring hormone levels into the typical male range, producing a more masculine body. Testosterone alone is usually sufficient; a separate anti-estrogen is not normally needed.

Medical disclaimer

This page summarises community guidance for educational purposes only. It is not medical advice. Dosing and monitoring should ideally be supervised by a qualified provider. See the source guides linked at the bottom.

Testosterone forms

The DIY HRT Directory covers four common forms, with example doses:

Form	Typical dose	Route & frequency
Testosterone Cypionate	50 mg weekly (range 20–100 mg)	subq or IM, weekly
Testosterone Enanthate	50 mg weekly (range 20–100 mg)	subq or IM, weekly
Testosterone Undecanoate	150–200 mg monthly, or 150 mg every 3 weeks	IM (depends on oil carrier)
Testosterone Gel (1% / 1.62% / 2%)	50 mg daily (up to 100 mg)	applied daily to shoulders, upper arms, or stomach

Routes. Cypionate and enanthate can be injected subcutaneously (subq) or intramuscularly (IM). Undecanoate is long-acting and injected less often. Gels are applied to the skin daily.

Target blood levels

The DIY HRT Directory aims for testosterone in the physiologic normal male range, cited per Endocrine Society guidelines as 300–1000 ng/dL, with estradiol kept around 10–50 pg/mL (ceiling ~70 pg/mL). See Blood Testing.

Expected effects

Testosterone typically produces a deeper voice, facial and body hair growth, fat redistribution, increased muscle mass, cessation of menstruation, and clitoral growth. Voice changes and, generally, hair growth are permanent; other effects may partly reverse if testosterone is stopped.

Monitor your blood count

Testosterone can raise hematocrit (red-blood-cell concentration). Elevated hematocrit (polycythemia) increases the risk of blood clots (thrombosis), so a complete blood count (CBC) should be part of routine monitoring — see Blood Testing.

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Sources: DIY HRT Directory — Transmasc guide, hrt.info.